Metastatic melanoma is challenging to manage. Although targeted-and immune therapies
have extended survival, most patients experience therapy resistance. The adaptability of …

Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …

INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective …

Inhibitors of cyclin-dependent kinases (CDKs) 4/6 have emerged as a powerful class of
agents with clinical activity in several malignancies. Targeting the cell cycle represents a …

Mutational activation of BRAF is the earliest and most common genetic alteration in human
melanoma. To build a model of human melanoma, we generated mice with conditional …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Cellular senescence, an irreversible proliferation arrest evoked by stresses such as
oncogene activation, telomere dysfunction, or diverse genotoxic insults, has been implicated …

Sequence polymorphisms linked to human diseases and phenotypes in genome-wide
association studies often affect noncoding regions. A SNP within an intron of the gene …

Tumor progression is a multistep process in which proproliferation mutations must be
accompanied by suppression of senescence. In melanoma, proproliferative signals are …

During the process of oncogenic transformation, melanoma cells escape from normal growth‐
control mechanisms and acquire the ability to invade surrounding tissues and organs. The …