Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of
model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1 …

Acetylation has recently emerged as an important mechanism for controlling a broad array of
proteins mediating cellular adaptation to metabolic fuels. Acetylation is governed, in part, by …

Emerging evidence suggests that protein acetylation is a broad-ranging regulatory
mechanism. Here we utilize acetyl-peptide arrays and metabolomic analyses to identify …

Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in
mitochondrial function contribute largely to the occurrence of CVDs. Recent studies suggest …