Antiviral CD8+ T cells respond to only a minute fraction of the potential peptide determinants
encoded by viral genomes. Immunogenic determinants can be ordered into highly …

Autophagy describes catabolic pathways that deliver cytoplasmic constituents for lysosomal
degradation. Since major histocompatibility complex (MHC) molecules sample protein …

Peptide antigens bound to molecules encoded by the major histocompatibility complex
(MHC) and presented on the cell surface form the targets of T lymphocytes. This critical arm …

INTRODUCTION Protein synthesis is controlled by a plethora of developmental and
environmental conditions. One intracellular signaling network, the integrated stress …

Subfemtomole peptide sequence analysis has been achieved using microcapillary HPLC
columns, with integrated nanoelectrospray emitters, coupled directly to a Fourier transform …

Current knowledge about the dynamics of antigen presentation to T cells during viral
infection is very poor despite being of fundamental importance to our understanding of anti …

CD8+ T cells respond to short peptides bound to MHC class I molecules. Although most
antigenic proteins contain many sequences that could bind to MHC class I, few of these …

Many components contribute to immunodominance in the response to a complex virus, but
their relative importance is unclear. This was addressed using vaccinia virus and HLA-A …

High-performance liquid chromatography (HPLC) is now firmly established as the premier
technique for the analysis and purification of a wide range of molecules. In particular, HPLC …

Experimental DNA vaccines comprised of multiple minimal cytotoxic T lymphocytes (CTL)
epitopes can effectively induce broad CTL responses; however, such constructs frequently …