Microglia activation as a biomarker for traumatic brain injury

DG Hernandez-Ontiveros, N Tajiri, S Acosta… - Frontiers in …, 2013 - frontiersin.org
Traumatic brain injury (TBI) has become the signature wound of wars in Afghanistan and
Iraq. Injury may result from a mechanical force, a rapid acceleration-deceleration movement …

New perspectives on central and peripheral immune responses to acute traumatic brain injury

M Das, S Mohapatra, SS Mohapatra - Journal of neuroinflammation, 2012 - Springer
Traumatic injury to the brain (TBI) results in a complex set of responses involving various
symptoms and long-term consequences. TBI of any form can cause cognitive, behavioral …

The role of BDNF in experimental and clinical traumatic brain injury

D Gustafsson, A Klang, S Thams… - International journal of …, 2021 - mdpi.com
Traumatic brain injury is one of the leading causes of mortality and morbidity in the world
with no current pharmacological treatment. The role of BDNF in neural repair and …

Traumatic brain injury in the elderly: is it as bad as we think?

CHK Mak, SKH Wong, GK Wong, S Ng… - Current translational …, 2012 - Springer
Traumatic brain injury in elderly patients is a neglected global disease burden. The main
cause is fall, followed by motor vehicle accidents. This review article summarizes different …

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44 and S100a4 as Treatment Targets

A Lipponen, J Paananen, N Puhakka, A Pitkänen - Scientific reports, 2016 - nature.com
We aimed to define the chronically altered gene expression signature of traumatic brain
injury (TBI-sig) to discover novel treatments to reverse pathologic gene expression or …

Alteration in long non-coding RNA expression after traumatic brain injury in rats

C Wang, C Zhao, W Weng, J Lei, Y Lin, Q Mao… - Journal of …, 2017 - liebertpub.com
Traumatic brain injury (TBI) causes a primary insult and initiates a secondary injury cascade.
The mechanisms underlying the secondary injury are multifactorial and may include the …

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

A Lipponen, A El-Osta, A Kaspi, M Ziemann… - Acta Neuropathologica …, 2018 - Springer
Traumatic brain injury (TBI) induces a wide variety of cellular and molecular changes that
can continue for days to weeks to months, leading to functional impairments. Currently, there …

Protective effects and regulatory pathways of melatonin in traumatic brain injury mice model: Transcriptomics and bioinformatics analysis

J Fu, Q Zhou, B Wu, X Huang, Z Tang, W Tan… - Frontiers in Molecular …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is the leading cause of disability and mortality globally.
Melatonin (Mel) is a neuroendocrine hormone synthesized from the pineal gland that …

Impact of traumatic brain injury on sleep structure, electrocorticographic activity and transcriptome in mice

M Sabir, PO Gaudreault, M Freyburger… - Brain, behavior, and …, 2015 - Elsevier
Traumatic brain injury (TBI), including mild TBI (mTBI), is importantly associated with
vigilance and sleep complaints. Because sleep is required for learning, plasticity and …

CD47 in the brain and neurodegeneration: an update on the role in neuroinflammatory pathways

SM Gheibihayat, R Cabezas, NG Nikiforov… - Molecules, 2021 - mdpi.com
CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed
on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and …