The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors
together with the discovery of their endogenous ligands in the late 80s and early 90s …

Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology
remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary …

Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …

Cannabinoids, the active components of cannabis (Cannabis sativa) extracts, have attracted
the attention of human civilizations for centuries, much earlier than the discovery and …

Prenatal cannabis exposure (PCE) influences human brain development, but it is
challenging to model PCE using animals and current cell culture techniques. Here, we …

The endocannabinoid system is known to regulate neural progenitor (NP) cell proliferation
and neurogenesis. In particular, CB 2 cannabinoid receptors have been shown to promote …

The adult mammalian brain can produce new neurons in a process called adult
neurogenesis, which occurs mainly in the subventricular zone (SVZ) and in the hippocampal …

Mesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of
several neurodegenerative disorders, including Alzheimer's disease (AD). The main …

In the past years, free fatty acids (FFAs) and obesity have been reported to play an important
role in cancer development. Palmitic acid (PA) is the most prevalent saturated FFA in …

Mental retardation in Down syndrome (DS) appears to be related to severe neurogenesis
impairment during critical phases of brain development. Recent lines of evidence in the …