Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array

K Hagiwara, T Murakami, G Xue, Y Shimizu… - Biochemical and …, 2010 - Elsevier
Although HIV-1 replication can be controlled by highly active anti-retroviral therapy (HAART)
using protease and reverse transcriptase inhibitors, the development of multidrug-resistant …

Synthesis of a Vpr-binding derivative for use as a novel HIV-1 inhibitor

K Hagiwara, H Ishii, T Murakami, S Takeshima… - Plos one, 2015 - journals.plos.org
The emergence of multidrug-resistant viruses compromises the efficacy of anti-human
immunodeficiency virus type 1 (HIV-1) therapy and limits treatment options. Therefore, new …