R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

R loops are three-stranded nucleic acid structures that comprise nascent RNA hybridized
with the DNA template, leaving the nontemplate DNA single-stranded. R loops form naturally …

Conflicts between transcription and replication are a potent source of DNA damage. Co-
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …

Genome instability is central to ageing, cancer and other diseases. It is not only proteins
involved in DNA replication or the DNA damage response (DDR) that are important for …

Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur
during DNA repair, chromosome duplication, and transmission or via recombination provide …

R loops are transcription byproducts that constitute a threat to genome integrity. Here we
show that R loops are tightly linked to histone H3 S10 phosphorylation (H3S10P), a mark of …

Aberrant R-loop structures are increasingly being realized as an important contributor to
human disease. R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids …

DNA-RNA hybrids associated with R-loops promote DNA damage and genomic instability.
The capacity of hybrids at different genomic sites to cause DNA damage was not known, and …

DNA: RNA hybrid formation is emerging as a significant cause of genome instability in
biological systems ranging from bacteria to mammals. Here we describe the genome-wide …

R-loops are three-stranded nucleic acid structures with both physiological and pathological
roles in cells. R-loop imaging generally relies on detection of the RNA–DNA hybrid …