[HTML][HTML] Targeted lactate dehydrogenase genes silencing in probiotic lactic acid bacteria: A possible paradigm shift in colorectal cancer treatment?

JM Macharia, Z Kaposztas, T Varjas, F Budán… - Biomedicine & …, 2023 - Elsevier
Even though the pathophysiology of colorectal cancer (CRC) is complicated and poorly
understood, interactions between risk factors appear to be key in the development and …

Medicinal Characteristics of Withania somnifera L. in Colorectal Cancer Management

JM Macharia, Z Káposztás, RL Bence - Pharmaceuticals, 2023 - mdpi.com
Research into tumorigenic pathways can aid in the development of more efficient cancer
therapies and provide insight into the physiological regulatory mechanisms employed by …

In silico evaluation of potential breast cancer receptor antagonists from GC-MS and HPLC identified compounds in Pleurotus ostreatus extracts

ME Effiong, M Bella-Omunagbe, IS Afolabi… - RSC …, 2024 - pubs.rsc.org
Introduction: Pharmacotherapeutic targets for breast cancer include the estrogen receptor
(ER), progesterone receptor (PR), and human epidermal growth factor receptor (EGFR) …

Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

JM Macharia, V Ngure, B Emődy, B Kiraly, Z Kaposztas… - Pharmaceutics, 2023 - mdpi.com
Aloe species are widespread and diverse in African ecosystems, and this commonly
correlates to their habitual use as reservoirs of herbal medicine. The side effects associated …

[HTML][HTML] Quercetin-induced pyroptosis in colon cancer through NEK7-mediated NLRP3 inflammasome-GSDMD signaling pathway activation

SH Feng, B Zhao, X Zhan, RH Li, Q Yang… - American Journal of …, 2024 - ncbi.nlm.nih.gov
Pyroptosis, a gasdermin-mediated lytic cell death, is a new hotspot topic in cancer research,
and induction of tumor pyroptosis has emerged as a new target in cancer management …

[HTML][HTML] Therapeutic effects of medicinal mushrooms on gastric, breast, and colorectal cancer: a scoping review

A Dan, R Swain, S Belonce, RJ Jacobs - Cureus, 2023 - ncbi.nlm.nih.gov
Cancer is the leading cause of mortality globally. With anticancer medications causing
severe adverse effects, understanding the role of alternative and efficacious anticancer …

The Impact of Palliative Care on Mitigating Pain and Its Associated Effects in Determining Quality of Life among Colon Cancer Outpatients

JM Macharia, BL Raposa, D Sipos, C Melczer, Z Toth… - Healthcare, 2023 - mdpi.com
Pain continues to be a significant problem for cancer patients, and the impact of a population-
based strategy on their experiences is not completely understood. Our study aimed to …

In Vitro Inhibition of Colorectal Cancer Gene Targets by Withania somnifera L. Methanolic Extracts: A Focus on Specific Genome Regulation

JM Macharia, DO Pande, A Zand, F Budán… - Nutrients, 2024 - mdpi.com
An approach that shows promise for quickening the evolution of innovative anticancer drugs
is the assessment of natural biomass sources. Our study sought to assess the effect of W …

Unearthing Nature's Pharmacy: Exploring the Antimicrobial Potency of Mushrooms

M Al Qutaibi, SR Kagne - Journal of Food Processing and …, 2024 - Wiley Online Library
The search for a new antibiotic or antifungal that could function efficiently without side effects
or inadequacies was always a dilemma. For centuries, mushrooms have been praised for …

The liquid by-product of biogas production: characterisation and impact on soil fungi

E Loffredo, C Carnimeo, N De Chirico… - Environmental …, 2024 - Taylor & Francis
ABSTRACT A liquid digestate (LD) obtained from the anaerobic digestion of mixed organic
waste was characterised and tested on the fungi Pleurotus eryngii, Irpex lacteus and …