Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motoneurons in
the cerebral cortex, brainstem and spinal cord. Neuroinflammation plays an important role in …

ATP is a (co) transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

P2X7 receptors (Rs) constitute a subclass of ATP-sensitive ionotropic receptors (P2X1-
P2X7). P2X7Rs have many distinguishing features, mostly based on their long intracellular …

Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection
and neuroregeneration. Initially there is a brief summary of the background of purinergic …

Purine nucleotides are well established as extracellular signaling molecules. P2X7
receptors (P2X7Rs) are members of the family of ionotropic ATP-gated receptors. Their …