Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin
filaments in fungi and metazoans. Tpms are coiled-coil parallel dimers that form a head-to …

The mitochondrial network constantly changes and remodels its shape to face the cellular
energy demand. In human cells, mitochondrial fusion is regulated by the large, evolutionarily …

Mitochondrial division requires division of both the inner and outer mitochondrial
membranes (IMM and OMM, respectively). Interaction with endoplasmic reticulum (ER) …

Mitochondrial fission is fundamentally important to cellular physiology. The dynamin-related
protein Drp1 mediates fission, and interaction between mitochondrion and endoplasmic …

Actin assembly and inward flow in the plane of the immunological synapse (IS) drives the
centralization of T cell receptor microclusters (TCR MCs) and the integrin leukocyte …

Bridging the gap between basic scientific advances and the understanding of liver disease—
the extensively revised new edition of the premier text in the field. The latest edition of The …

A tendency in cell biology is to divide and conquer. For example, decades of painstaking
work have led to an understanding of endoplasmic reticulum (ER) and Golgi structure …

Drp1 is a dynamin guanosine triphosphatase important for mitochondrial and peroxisomal
division. Drp1 oligomerization and mitochondrial recruitment are regulated by multiple …

Actin has well established functions in cellular morphogenesis. However, it is not well
understood how the various actin assemblies in a cell are kept in a dynamic equilibrium, in …

Heterozygosity for inverted formin-2 (INF2) mutations causes focal segmental
glomerulosclerosis (FSGS) with or without Charcot-Marie-Tooth disease. A key question is …