T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …

The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that
binds to LFA3, a cell surface protein expressed on eg, antigen-presenting cells. CD2 has an …

The cell-autonomous balance of immune-inhibitory and-stimulatory signals is a critical
process in cancer immune evasion. Using patient-derived co-cultures, humanized mouse …

CD48, a member of the signaling lymphocyte activation molecule family, participates in
adhesion and activation of immune cells. Although constitutively expressed on most …

CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in
mice and CD58 in humans, that are present on antigen-presenting cells (APCs). However …

The protein-protein interaction underlying l&and recogmtion by CD2 must ensure sprcifuty
while allowing for wry weak binding. The CD5Rbmdmg site on human CD2 has nuw brrn …

2B4 is a cell surface glycoprotein related to CD2 and implicated in the regulation of natural
killer and T lymphocyte function. A recombinant protein containing the extracellular region of …

The folding energetics of the mono-N-glycosylated adhesion domain of the human immune
cell receptor cluster of differentiation 2 (hCD2ad) were studied systematically to understand …

Interaction between CD2 and its counterreceptor, CD58 (LFA-3), on opposing cells
optimizes immune recognition, facilitating contacts between helper T lymphocytes and …

To determine events that transpire during the earliest stages of human T cell development,
we have studied fetal tissues before (7 wk), during (8.2 wk), and after (9.5 wk to birth) …