The contribution of copy number variants to psychiatric symptoms and cognitive ability
Copy number variants (CNVs) are deletions and duplications of DNA sequence. The most
frequently studied CNVs, which are described in this review, are recurrent CNVs that occur …
frequently studied CNVs, which are described in this review, are recurrent CNVs that occur …
Hidden role of gut microbiome dysbiosis in schizophrenia: Antipsychotics or psychobiotics as therapeutics?
N Munawar, K Ahsan, K Muhammad, A Ahmad… - International journal of …, 2021 - mdpi.com
Schizophrenia is a chronic, heterogeneous neurodevelopmental disorder that has complex
symptoms and uncertain etiology. Mounting evidence indicates the involvement of genetics …
symptoms and uncertain etiology. Mounting evidence indicates the involvement of genetics …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …
Schizophrenia and the neurodevelopmental continuum: evidence from genomics
MJ Owen, MC O'Donovan - World Psychiatry, 2017 - Wiley Online Library
The idea that disturbances occurring early in brain development contribute to the
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
P Steullet, JH Cabungcal, J Coyle, M Didriksen… - Molecular …, 2017 - nature.com
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …
The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
By performing a meta-analysis of rare coding variants in whole-exome sequences from
4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and …
4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and …
Cognitive performance among carriers of pathogenic copy number variants: analysis of 152,000 UK Biobank subjects
Abstract Background The UK Biobank is a unique resource for biomedical research, with
extensive phenotypic and genetic data on half a million adults from the general population …
extensive phenotypic and genetic data on half a million adults from the general population …
Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants
Purpose To assess the contribution of rare variants in the genetic background toward
variability of neurodevelopmental phenotypes in individuals with rare copy-number variants …
variability of neurodevelopmental phenotypes in individuals with rare copy-number variants …
[HTML][HTML] Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia
We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We …
association between the disorder and chromosomal copy number (CNV) burden. We …
Copy number variation in bipolar disorder
Abstract Large (> 100 kb), rare (< 1% in the population) copy number variants (CNVs) have
been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) …
been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) …