Regenerative therapies for spinal cord injury

N Ashammakhi, HJ Kim, A Ehsanipour… - … Engineering Part B …, 2019 - liebertpub.com
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged
adults at its onset. To date, no effective regenerative treatment has been developed. Over …

Current options for cell therapy in spinal cord injury

I Vismara, S Papa, F Rossi, G Forloni… - Trends in molecular …, 2017 - cell.com
Spinal cord injury (SCI) is a complex pathology that evolves after primary acute mechanical
injury, causing further damage to the spinal cord tissue that exacerbates clinical outcomes …

Role and prospects of regenerative biomaterials in the repair of spinal cord injury

S Liu, YY Xie, B Wang - Neural regeneration research, 2019 - journals.lww.com
Axonal junction defects and an inhibitory environment after spinal cord injury seriously
hinder the regeneration of damaged tissues and neuronal functions. At the site of spinal cord …

Decellularized brain matrix enhances macrophage polarization and functional improvements in rat spinal cord injury

JY Hong, Y Seo, G Davaa, HW Kim, SH Kim, JK Hyun - Acta biomaterialia, 2020 - Elsevier
Spinal cord injury (SCI) is a devastating lesion lacking effective treatment options currently
available in clinics. The inflammatory process exacerbates the extent of the lesion through a …

Design of hydrogel-based scaffolds for the treatment of spinal cord injuries

N Ghane, MH Beigi, S Labbaf… - Journal of Materials …, 2020 - pubs.rsc.org
Spinal cord injury (SCI) is a traumatic lesion that diminishes sensory and/or motor neuronal
functionality, directly affecting the quality of the patient's life. Due to the central nervous …

Stem cell paracrine effect and delivery strategies for spinal cord injury regeneration

V Veneruso, F Rossi, A Villella, A Bena… - Journal of Controlled …, 2019 - Elsevier
Spinal cord injury (SCI) is a complicated neuropathological condition that results in
functional dysfunction and paralysis. Various treatments have been proposed including …

Application of stem cells in regeneration medicine

Y Jin, S Li, Q Yu, T Chen, D Liu - MedComm, 2023 - Wiley Online Library
Regeneration is a complex process affected by many elements independent or combined,
including inflammation, proliferation, and tissue remodeling. Stem cells is a class of primitive …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

Berberine loaded chitosan nanoparticles encapsulated in polysaccharide-based hydrogel for the repair of spinal cord

S Mahya, J Ai, S Shojae, HA Khonakdar… - International Journal of …, 2021 - Elsevier
The potential of berberine loaded in chitosan nanoparticles (BerNChs) within a hybrid of
alginate (Alg) and chitosan (Ch) hydrogel was investigated for the substrate which is known …

PCL/gelatin nanofibrous scaffolds with human endometrial stem cells/Schwann cells facilitate axon regeneration in spinal cord injury

H Babaloo, S Ebrahimi‐Barough… - Journal of cellular …, 2019 - Wiley Online Library
The significant consequences of spinal cord injury (SCI) include sensory and motor disability
resulting from the death of neuronal cells and axon degeneration. In this respect …