Double-strand break repair: 53BP1 comes into focus
S Panier, SJ Boulton - Nature reviews Molecular cell biology, 2014 - nature.com
DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic
integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important …
integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important …
[HTML][HTML] Chromatin modifications and their function
T Kouzarides - Cell, 2007 - cell.com
The surface of nucleosomes is studded with a multiplicity of modifications. At least eight
different classes have been characterized to date and many different sites have been …
different classes have been characterized to date and many different sites have been …
[HTML][HTML] Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
MV Botuyan, J Lee, IM Ward, JE Kim, JR Thompson… - Cell, 2006 - cell.com
Histone lysine methylation has been linked to the recruitment of mammalian DNA repair
factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs) …
factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs) …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
Abstract p53-binding protein 1 (53BP1) is known to be an important mediator of the DNA
damage response, with dimethylation of histone H4 lysine 20 (H4K20me2) critical to the …
damage response, with dimethylation of histone H4 lysine 20 (H4K20me2) critical to the …
The emerging role of nuclear architecture in DNA repair and genome maintenance
T Misteli, E Soutoglou - Nature reviews Molecular cell biology, 2009 - nature.com
DNA repair and maintenance of genome stability are crucial to cellular and organismal
function, and defects in these processes have been implicated in cancer and ageing …
function, and defects in these processes have been implicated in cancer and ageing …
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
G Schotta, R Sengupta, S Kubicek, S Malin… - Genes & …, 2008 - genesdev.cshlp.org
H4K20 methylation is a broad chromatin modification that has been linked with diverse
epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct …
epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct …
Assembly and function of DNA double-strand break repair foci in mammalian cells
S Bekker-Jensen, N Mailand - DNA repair, 2010 - Elsevier
DNA double-strand breaks (DSBs) are among the most cytotoxic types of DNA damage,
which if left unrepaired can lead to mutations or gross chromosomal aberrations, and …
which if left unrepaired can lead to mutations or gross chromosomal aberrations, and …
Genomic integrity and the ageing brain
H Chow, K Herrup - Nature Reviews Neuroscience, 2015 - nature.com
DNA damage is correlated with and may drive the ageing process. Neurons in the brain are
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …
Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks
P Langerak, E Mejia-Ramirez, O Limbo… - PLoS genetics, 2011 - journals.plos.org
The multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1
checkpoint kinase and CtIP/Ctp1 homologous recombination (HR) repair factor to double …
checkpoint kinase and CtIP/Ctp1 homologous recombination (HR) repair factor to double …