Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Imaging mass spectrometry

LA McDonnell, RMA Heeren - Mass spectrometry reviews, 2007 - Wiley Online Library
Imaging mass spectrometry combines the chemical specificity and parallel detection of mass
spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain …

Sample preparation for mass spectrometry imaging of plant tissues: a review

Y Dong, B Li, S Malitsky, I Rogachev… - Frontiers in plant …, 2016 - frontiersin.org
Mass spectrometry imaging (MSI) is a mass spectrometry based molecular ion imaging
technique. It provides the means for ascertaining the spatial distribution of a large variety of …

Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development

EG Solon, A Schweitzer, M Stoeckli, B Prideaux - The AAPS journal, 2010 - Springer
Abstract Whole-body autoradiography ((WBA) or quantitative WBA (QWBA)),
microautoradiography (MARG), matrix-assisted laser desorption/ionization mass …

Biological tissue imaging with time‐of‐flight secondary ion mass spectrometry and cluster ion sources

A Brunelle, D Touboul… - Journal of mass …, 2005 - Wiley Online Library
Time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) using liquid metal ion guns
(LMIGs) is now sensitive enough to produce molecular‐ion images directly from biological …

Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry

AFM Altelaar, I Klinkert, K Jalink… - Analytical …, 2006 - ACS Publications
Surface metallization by plasma coating enhances desorption/ionization of membrane
components such as lipids and sterols in imaging time-of-flight secondary ion mass …

Silver-assisted laser desorption ionization for high spatial resolution imaging mass spectrometry of olefins from thin tissue sections

M Dufresne, A Thomas, J Breault-Turcot… - Analytical …, 2013 - ACS Publications
Silver has been demonstrated to be a powerful cationization agent in mass spectrometry
(MS) for various olefinic species such as cholesterol and fatty acids. This work explores the …

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

P Massonnet, RMA Heeren - Journal of Analytical Atomic Spectrometry, 2019 - pubs.rsc.org
This concise tutorial review provides a description of the current state of the art in the
application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field …

Colloidal Graphite-Assisted Laser Desorption/Ionization Mass Spectrometry and MSn of Small Molecules. 1. Imaging of Cerebrosides Directly from Rat Brain Tissue

S Cha, ES Yeung - Analytical chemistry, 2007 - ACS Publications
Graphite-assisted laser desorption/ionization (GALDI) mass spectrometry (MS) was
investigated for analysis of cerebrosides in a complex total brain lipid extract. Conventional …

Imaging mass spectrometry: fundamentals and applications to drug discovery

SS Rubakhin, JC Jurchen, EB Monroe, JV Sweedler - Drug discovery today, 2005 - Elsevier
Imaging mass spectrometry (IMS) encompasses a variety of techniques that enable the
chemical imaging of analytes, which range in size from atoms and small molecules to intact …