With the emergence of the new field of molecular imaging, there is an increasing demand for
development of sensitive and safe novel imaging agents that can be rapidly translated from …

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central
nervous system. This paper reviews the current knowledge derived from positron emission …

A single-tissue compartment model with plasma input is the established method for
analysing [11C] flumazenil ([11C] FMZ) studies. However, arterial cannulation and …

In positron emission tomography (PET) studies, the detailed mapping of neuroreceptor
binding is a trade-off between parametric accuracy and spatial precision. Logan's graphical …

The study of human neuroreceptor systems by means of positron emission tomography
(PET) and suitable radioligands has proven to be of great importance in research on normal …

Recently, reference tissue methods have been proposed to estimate binding potential from
PET data. A reference region without specifically bound ligand is used as an indirect input …

Abstract Although [11C] Ro15‐4513 and [11C] flumazenil both bind to the central
benzodiazepine (BZ) receptors, the distributions of the two ligands are not identical in vivo …

Purpose: To evaluate the changes of the inhibitory neurotransmitter receptor system related
to epileptogenesis by measuring central benzodiazepine receptors (BZDRs) in surgically …

Understanding the effects of tobacco smoking on neuroadaptations in GABAA receptor
levels over alcohol withdrawal will provide critical insights for the treatment of comorbid …

The distribution of benzodiazepine receptors in the human brain has been widely studied
with SPECT using 123I-iomazenil and semiquantitative approaches, but these methods do …