Box-Behnken design: an alternative for the optimization of analytical methods

SLC Ferreira, RE Bruns, HS Ferreira, GD Matos… - Analytica chimica …, 2007 - Elsevier
The present paper describes fundamentals, advantages and limitations of the Box-Behnken
design (BBD) for the optimization of analytical methods. It establishes also a comparison …

Chemometrics approaches to green analytical chemistry procedure development

K Kalinowska, M Bystrzanowska… - Current Opinion in Green …, 2021 - Elsevier
Chemometric tools are widely used in analytical chemistry for the reduction of data
dimensionality, grouping of variables, and processing of analytical signals. They have also …

[HTML][HTML] The desirability optimization methodology; a tool to predict two antagonist responses in biotechnological systems: case of biomass growth and hyoscyamine …

R Amdoun, L Khelifi, M Khelifi-Slaoui… - Iranian Journal of …, 2018 - ncbi.nlm.nih.gov
Background The use of the desirability function approach combined with the response
surface methodology (RSM), also called Desirability Optimization Methodology (DOM), has …

Simultaneous determination of multiresidue and multiclass emerging contaminants in waters by rotating-disk sorptive extraction–derivatization-gas chromatography …

D Arismendi, M Becerra-Herrera, I Cerrato, P Richter - Talanta, 2019 - Elsevier
An efficient method has been developed for the multiresidue and multiclass determination of
16 emerging contaminants (parabens, hormones, anti-inflammatory drugs, triclosan and …

In‐line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models

H Bhatia, H Mehdizadeh, D Drapeau… - Engineering in Life …, 2018 - Wiley Online Library
The application of PAT for in‐line monitoring of biopharmaceutical manufacturing operations
has a central role in developing more robust and consistent processes. Various …

Medium optimization by combination of response surface methodology and desirability function: an application in glutamine production

J Li, C Ma, Y Ma, Y Li, W Zhou, P Xu - Applied microbiology and …, 2007 - Springer
An optimization strategy based on desirability function approach (DFA) together with
response surface methodology (RSM) has been used to optimize production medium in L …

Multi-criteria decision making approach and experimental design as chemometric tools to optimize HPLC separation of domperidone and pantoprazole

T Sivakumar, R Manavalan, C Muralidharan… - … of Pharmaceutical and …, 2007 - Elsevier
This paper deals with multiple response simultaneous optimization using the Derringer's
desirability function for the development of a reversed-phase HPLC method for the …

Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and …

E Nemutlu, S Kır, D Katlan, MS Beksac - Talanta, 2009 - Elsevier
An HPLC method for the separation of seven cephalosporins [Cefepime (CEP), ceftazidime
(CTA), ceftizaxime (CTI), ceftriaxone (CTR), cefotaxime (COT), cefixime (CIX) and …

Models and objective functions for the optimisation of selectivity in reversed-phase liquid chromatography

MC García-Álvarez-Coque, JR Torres-Lapasió… - Analytica chimica …, 2006 - Elsevier
Interpretive methodologies are the most efficient tools for finding the optimal conditions in
chromatography. These methodologies are supported by models or algorithms able to infer …

[HTML][HTML] Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: Analytics, applications, implications and future prospects

SB Ganorkar, AA Shirkhedkar - Reviews in Analytical Chemistry, 2017 - degruyter.com
This review presents the essential brief annals, crucial analytics, precise applications and
noteworthy implications of design of experiments which enrouted to liquid chromatography …