Experiences, whether they be learning in a classroom, a stressful event, or ingestion of a
psychoactive substance, impact the brain by modifying the activity and organization of …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Although astrocytes constitute nearly half of the cells in our brain, their function is a long-
standing neurobiological mystery. Here we show by quantal analyses, FM1-43 imaging …

▪ Abstract Membrane fusion involves the merger of two phospholipid bilayers in an aqueous
environment. In artificial lipid bilayers, fusion proceeds by means of defined transition states …

Stimulus-secretion coupling is an essential process in secretory cells in which regulated
exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While …

An abundant presynaptic protein, α-synuclein, is centrally involved in the pathogenesis of
Parkinson's disease. However, conflicting data exist about the normal function of α …

Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target
in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor …

Noncoding variants in the human MIR137 gene locus increase schizophrenia risk with
genome-wide significance. However, the functional consequence of these risk alleles is …

We have generated mice lacking synaptogyrin I and synaptophysin I to explore the functions
of these abundant tyrosine-phosphorylated proteins of synaptic vesicles. Single and double …

The hippocampal mossy fiber pathway between the granule cells of the dentate gyrus and
the pyramidal cells of area CA3 has been the target of numerous scientific studies. Initially …