The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many
neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic …

Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …

Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …

Treatment and prevention strategies for schizophrenia require knowledge about the
mechanisms involved in the psychotic transition. Increasing evidence suggests a redox …

Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its
own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a …

The pathogenesis and etiology of schizophrenia (SCZ) remains unclear. Accumulating
studies showed that complex interrelationships between brain-derived neurotrophic factor …

Background: Glutathione is among the important antioxidants to prevent oxidative stress.
However, the relationships between abnormality in the glutathione system and …

The biochemical integrity of the brain is paramount to the function of the central nervous
system, and oxidative stress is a key contributor to cerebral biochemical impairment …

While neurotransmitter dysfunction represents a key component in mental illnesses, there is
now a wide agreement for a central pathophysiological hub that includes hormones …