Broadly neutralizing antibodies to HIV and their role in vaccine design
DR Burton, L Hangartner - Annual review of immunology, 2016 - annualreviews.org
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
R Rappuoli, MJ Bottomley, U D'Oro, O Finco… - Journal of Experimental …, 2016 - rupress.org
Traditionally, vaccines have been developed by cultivating infectious agents and isolating
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …
A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques
The development of a protective vaccine remains a top priority for the control of the HIV/AIDS
pandemic. Here, we show that a messenger RNA (mRNA) vaccine co-expressing …
pandemic. Here, we show that a messenger RNA (mRNA) vaccine co-expressing …
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity
Saponins are potent and safe vaccine adjuvants, but their mechanisms of action remain
incompletely understood. Here, we explored the properties of several saponin formulations …
incompletely understood. Here, we explored the properties of several saponin formulations …
[HTML][HTML] Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
KM Cirelli, DG Carnathan, B Nogal, JT Martin… - Cell, 2019 - cell.com
Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination
Natural infections expose the immune system to escalating antigen and inflammation over
days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the …
days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the …
Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer
The envelope glycoprotein trimer (Env) on the surface of HIV-1 recognizes CD4+ T cells and
mediates viral entry. During this process, Env undergoes substantial conformational …
mediates viral entry. During this process, Env undergoes substantial conformational …
Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G
Summary The HIV-1-envelope (Env) trimer is covered by a glycan shield of∼ 90 N-linked
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches
M Pauthner, C Havenar-Daughton, D Sok, JP Nkolola… - Immunity, 2017 - cell.com
The development of stabilized recombinant HIV envelope trimers that mimic the virion
surface molecule has increased enthusiasm for a neutralizing antibody (nAb)-based HIV …
surface molecule has increased enthusiasm for a neutralizing antibody (nAb)-based HIV …