The role of polyphenol (flavonoids) compounds in the treatment of cancer cells

A Hazafa, KU Rehman, N Jahan, Z Jabeen - Nutrition and cancer, 2020 - Taylor & Francis
Cancer remains a second leading cause of deaths and major public health problem. It
occurs due to extensive DNA damage caused by ultraviolet radiations, ionizing radiations …

Natural small molecules in breast cancer treatment: understandings from a therapeutic viewpoint

MR Islam, F Islam, MH Nafady, M Akter, S Mitra, R Das… - Molecules, 2022 - mdpi.com
Breast cancer (BrCa) is the most common malignancy in women and the second most
significant cause of death from cancer. BrCa is one of the most challenging malignancies to …

Recent discoveries of anticancer flavonoids

D Raffa, B Maggio, MV Raimondi, F Plescia… - European journal of …, 2017 - Elsevier
In this review we report the recent advances in anticancer activity of the family of natural
occurring flavonoids, covering the time span of the last five years. The bibliographic data will …

The role of tumor inflammatory microenvironment in lung cancer

Z Tan, H Xue, Y Sun, C Zhang, Y Song… - Frontiers in …, 2021 - frontiersin.org
Lung cancer is the most common and fatal malignant tumor in the world. The tumor
microenvironment (TME) is closely related to the occurrence and development of lung …

Terpenoids' anti-cancer effects: Focus on autophagy

C El-Baba, A Baassiri, G Kiriako, B Dia, S Fadlallah… - Apoptosis, 2021 - Springer
Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

Understanding the effectiveness of natural compound mixtures in cancer through their molecular mode of action

TN Aung, Z Qu, RD Kortschak, DL Adelson - International journal of …, 2017 - mdpi.com
Many approaches to cancer management are often ineffective due to adverse reactions,
drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a …

PI3K/Akt signaling in osteosarcoma

J Zhang, XH Yu, YG Yan, C Wang, WJ Wang - Clinica chimica acta, 2015 - Elsevier
Osteosarcoma (OS) is the most common nonhematologic bone malignancy in children and
adolescents. Despite the advances of adjuvant chemotherapy and significant improvement …

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

H Gali-Muhtasib, R Hmadi, M Kareh, R Tohme… - Apoptosis, 2015 - Springer
Despite remarkable progress in the discovery and development of novel cancer
therapeutics, cancer remains the second leading cause of death in the world. For many …

Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets

K Banik, AM Ranaware, V Deshpande… - Pharmacological …, 2019 - Elsevier
In spite of billions of dollars expended on cancer research every year, the incidence rate and
the mortality rate due to this widespread disease has increased drastically over the last few …

Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review

I Faraone, C Sinisgalli, A Ostuni, MF Armentano… - Pharmacological …, 2020 - Elsevier
During the latest decades, the interest on the effectiveness of natural compounds and their
impact on human health constantly increased, especially on those demonstrating to be …