Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …

Sigma-2 receptor is a widely distributed protein, which can modulate cell proliferation and
involved in the pathogenesis of tumor. Photoaffinity labelling techniques testified that its …

In this study, a panel of 46 compounds containing five different scaffolds known to have high
σ2 receptor affinity were screened. 6, 7-Dimethoxy-2-[4-(4-methoxyphenyl) butan-2-yl]-1, 2 …

This study presents for the first time the 3D model of the σ1 receptor protein as obtained from
homology modeling techniques, shows the applicability of this structure to docking-based …

Novel benzo [d] oxazol-2 (3 H)-one derivatives were designed and synthesized, and their
affinities against σ receptors were evaluated. On the basis of 31 compounds, a three …

Sigma1 Receptor (S1R) is involved in oxidative stress, since its activation is triggered by
oxidative or endoplasmic reticulum stress. Since specific aquaporins (AQP), called …

The enantiomers of four chiral 3-aryl-substituted-γ-butyrolactones, key intermediates for the
preparation of compounds of pharmaceutical interest, were successfully isolated by …

The human Sigma1 receptor (S1R), which has been identified as a target with an important
role in neuropsychological disorders, was first crystallized 3 years ago. Since S1R structure …

Originally considered an enigmatic polypeptide, the σ1 receptor has recently been identified
as a unique ligand-regulated protein. Many studies have shown the potential of σ1 receptor …

In this work we developed a 3D-pharmacophore model for σ2 receptor based on 19
benzooxazolone derivatives. The best 3D-pharmacophore hypothesis, consisting of five …