Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

Rights, interests and expectations: Indigenous perspectives on unrestricted access to genomic data

M Hudson, NA Garrison, R Sterling, NR Caron… - Nature Reviews …, 2020 - nature.com
Addressing Indigenous rights and interests in genetic resources has become increasingly
challenging in an open science environment that promotes unrestricted access to genomic …

African genetic diversity and adaptation inform a precision medicine agenda

L Pereira, L Mutesa, P Tindana, M Ramsay - Nature Reviews Genetics, 2021 - nature.com
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

Evaluating the promise of inclusion of African ancestry populations in genomics

AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

Promoting the genomic revolution in Africa through the Nigerian 100K Genome Project

S Fatumo, A Yakubu, O Oyedele, J Popoola… - Nature Genetics, 2022 - nature.com
To leverage the genetic diversity in Nigeria, we established the Non-Communicable
Diseases Genetic Heritage Study (NCD-GHS) consortium to help produce a comprehensive …

Five priorities of African genomics research: the next frontier

A Wonkam, NS Munung, C Dandara… - Annual Review of …, 2022 - annualreviews.org
To embrace the prospects of accurately diagnosing thousands of monogenic conditions,
predicting disease risks for complex traits or diseases, tailoring treatment to individuals' …

Boots on the ground in Africa's ancient DNA 'revolution': archaeological perspectives on ethics and best practices

ME Prendergast, E Sawchuk - Antiquity, 2018 - cambridge.org
Recent methodological advances have increased the pace and scale of African ancient
DNA (aDNA) research, inciting a rush to sample broadly from museum collections, and …

[HTML][HTML] Defining and achieving health equity in genomic medicine

S Jooma, MJ Hahn, LA Hindorff, VL Bonham - Ethnicity & disease, 2019 - ncbi.nlm.nih.gov
The potential of genomics to improve health comes with the peril that the benefits will not be
equitably available to all populations. Existing health disparities can be exacerbated if the …

Handling ethics dumping and neo-colonial research: from the laboratory to the academic literature

JA Teixeira da Silva - Journal of bioethical inquiry, 2022 - Springer
This paper explores that the topic of ethics dumping (ED), its causes and potential remedies.
In ED, the weaknesses or gaps in ethics policies and systems of lower income countries are …

Bioengineering horizon scan 2020

L Kemp, L Adam, CR Boehm, R Breitling… - Elife, 2020 - elifesciences.org
Horizon scanning is intended to identify the opportunities and threats associated with
technological, regulatory and social change. In 2017 some of the present authors conducted …