Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …

Much progress has been made in the last decade in identifying genes responsible for
antifungal resistance in Candida albicans. Attention has focused on five major C. albicans …

Infections by fungal pathogens such as Candida albicans and Aspergillus fumigatus and
their resistance to triazole drugs are major concerns. Fungal lanosterol 14α-demethylase …

There are relatively few classes of antifungal drugs. This restricts clinicians' therapeutic
choices and these choices are further reduced by the emergence of drug resistance …

Fungi comprise a minor component of the oral microbiota but give rise to oral disease in a
significant proportion of the population. The most common form of oral fungal disease is oral …

Overexpression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is
often responsible for the failure of chemotherapy as a treatment for human tumors. The …

Resistance mechanisms can be engaged in clinically relevant fungal pathogens under
different conditions when exposed to antifungal drugs. Over past years, active research was …

Resistance to antifungal drugs is an increasingly significant clinical problem. The most
common antifungal resistance encountered is efflux pump-mediated resistance of Candida …

One of the major advances serving to define the beginning of the era of modern medicine
was the development of penicillin in the early 1940s as the first widely used antibiotic …

In the present study we have exploited isogenic erg mutants of Saccharomyces cerevisiae to
examine the contribution of an altered lipid environment on drug susceptibilities of yeast …