As a chronic progressive autoimmune disease, rheumatoid arthritis (RA) is characterized by
mainly damaging the synovium of peripheral joints and causing joint destruction and early …

Extracellular vesicles (EV) can be produced as part of pathology and physiology with
increased amounts in pathological conditions. EVs can carry and transfer cargo such as …

Objectives Alterations in tryptophan (Trp) metabolism have been reported in inflammatory
diseases, including rheumatoid arthritis (RA). However, understanding whether these …

Evidence demonstrates that T cells are implicated in developing SLE, and each of them
dominantly uses distinct metabolic pathways. Indeed, intracellular enzymes and availability …

Clobenpropit is a histamine H3 receptor antagonist and has developed as a potential
therapeutic drug due to its ability to inhibit CXCR4, a chemokine receptor involved in …

Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint damage and
physical dysfunction. The pathogenesis of RA is highly complex, involving genetic …

OBJECTIVE: Rheumatoid arthritis (RA), as an autoimmune disease, poses a huge social
and economic burden worldwide. Although the diagnosis of RA has been gradually …

Objective To elucidate the association between the changes in intracellular metabolism in
the early stage of B cell activation and systemic lupus erythematosus (SLE) pathogenesis …

The article delves into the pathogenesis of systemic sclerosis (SSc) with an emphasis on
immunometabolism dysfunctions. SSc is a complex autoimmune connective tissue disorder …

Background Reducing inflammation is central to the management of RA. However,
commonly used markers such as CRP and ESR, along with the DAS-28 score, have shown …