99mTc-linezolid as a radiotracer for brain abscess: labeling, in silico docking, and biodistribution studies

OA El-Kawy, IT Ibrahim, HA Shweeta… - Applied Radiation and …, 2023 - Elsevier
Brain abscess is a life-threatening condition that requires a timely and accurate diagnosis. In
this study, linezolid, an oxazolidinone antibiotic, was labeled with technetium-99m according …

Radioiodination, nasal nanoformulation and preliminary evaluation of isovanillin: a new potential brain cancer-targeting agent

OA El-Kawy, HA Shweeta, KM Attallah - Applied Radiation and Isotopes, 2022 - Elsevier
Brain cancer is a challenging disease to treat using conventional approaches. The present
investigation aimed to develop a radiopharmaceutical targeting brain cancer based on …

Dual-Modality Nanoprobe for Noninvasive Detection of Microthrombus after Cerebral Ischemia/Reperfusion

X Xu, T Xu, D Liu, J Ding, D Chang… - ACS Applied Nano …, 2024 - ACS Publications
The presence of cerebral ischemia/reperfusion (CI/R) poses a significant impediment to the
complete restoration of neuronal functioning following the onset of ischemic stroke and the …

Preparation and evaluation of radiolabeled gliclazide parenteral nanoemulsion as a new tracer for pancreatic β-cells mass

OA El-Kawy, IT Ibrahim, HA Shewatah… - International Journal of …, 2023 - Taylor & Francis
Purpose The present investigation aims to develop and evaluate a radiopharmaceutical for
targeting and assessing β-cells mass based on gliclazide, an antidiabetic drug that …

Preparation and preliminary evaluation study of [131I]iodocolchicine-gallic-AuNPs: a potential scintigraphic agent for inflammation detection

BM Essa, AA Selim, OA El-Kawy… - International journal of …, 2022 - Taylor & Francis
Background Nanomedicine offers great potential for scintigraphic diagnostic imaging with
lower risk and higher quality compared to other traditional techniques. Objectives This work …

Radiolabeling, characterization, and preclinical evaluation of plazomicin: A potential tracer for bacterial infection

OA El‐kawy, G Abdelaziz… - Chemical Biology & …, 2022 - Wiley Online Library
In this study, 99mTc–plazomicin, a new radio‐antibiotic complex, was prepared specifically
for bacterial infection localization and monitoring. Factors affecting the labeling reaction …

99mTc-labeled glimepiride as a tracer for targeting pancreatic β-cells mass: preparation and preclinical evaluation

OA El-Kawy, JA García-Horsman - Journal of Radioanalytical and Nuclear …, 2017 - Springer
Complexation of glimepiride with 99m Tc, factors affecting yield and suitability of the 99m Tc-
glimepiride as a tracer for pancreatic β-cells mass were investigated. The radiocomplex …

TrisOxine abiotic siderophores for technetium complexation: radiolabeling and biodistribution studies

J Leenhardt, A Biguet Petit Jean, F Raes… - EJNMMI …, 2023 - Springer
Background Despite the development of positron emission tomography (PET), single photon
emission computed tomography (SPECT) still accounts for around 80% of all examinations …

Preparation and evaluation of 99mTc-anidulafungin: a potential radiotracer for fungal infection

OA El-Kawy, MS Sayed, AS Abdel-Razek - Journal of Radioanalytical and …, 2020 - Springer
Aiming to develop specific diagnostic tool for invasive fungal infection, a
radiopharmaceutical based on anidulafungin was investigated. A two-step approach was …

Preparation and evaluation of radioiodinated avanafil: A novel potential radiopharmaceutical for the diagnostic evaluation of erectile dysfunction

OA El-Kawy, IT Ibrahim, HA Shewatah… - Applied Radiation and …, 2022 - Elsevier
Avanafil, a selective second-generation phosphodiesterase-5 inhibitor, was successfully
labeled with iodine-125 via electrophilic and different factors affecting the labeling efficiency …