Alzheimer's disease (AD) is the most common form of dementia and cases are rising
worldwide. The effort to fight this disease is hampered by a lack of disease-modifying …

Necroptosis, or programmed necrosis, involves the kinase activity of receptor interacting
kinases 1 and 3, the activation of the pseudokinase mixed lineage kinase domain‐like and …

Blood-based tests have sparked tremendous attention in non-invasive early diagnosis of
Alzheimer's disease (AD), a most prevalent neurodegenerative malady worldwide. Despite …

Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should
be objective and quantifiable and respond to specific therapeutic interventions. Optimal …

Novel technologies such as single-cell RNA and single-nucleus RNA sequencing have
shed new light on the complexity of different microglia populations in physiological and …

The balance between neurodegeneration, neuroinflammation, neuroprotection, and COVID-
19-directed therapy may underly the heterogeneity of SARS-CoV-2′ s neurological …

Introduction The substantial link between apolipoprotein E (APOE) ε4 allele and oxidative
stress may underlie enhanced Alzheimer's disease (AD) risk. Here, we studied the impact of …

Tetrapod endogenous retroelements (ERE) encode proteins that have been exapted to
perform many roles in development and also in innate immunity, including GAG (group …

Amyloid-beta clearance plays a key role in the pathogenesis of Alzheimer's disease.
However, the variation in functional proteins involved in amyloid-beta clearance and their …

阿尔茨海默病(AD) 是一种严重威胁人类健康的疾病, 也是引起人类死亡的三大因素之一.
双链RNA 依赖的蛋白激酶(PKR) 又称为前炎症细胞因子, 是人类先天免疫干扰素刺激因子之一 …