Heat shock proteins (Hsp) are a diverse group of constitutive and/or stress-induced
molecules that are categorized into several classes on the basis of their molecular weight …

Bullous pemphigoid and pemphigus constitute two major autoimmune blistering diseases
(AIBD) with complicated disease pathomechanisms involving a multitude of cytokines and …

Introduction Chronic inflammatory skin diseases may have a profound negative impact on
the quality of life. Current treatment options may be inadequate, offering an unsatisfactory …

Heat shock proteins (HSPs), a large group of highly evolutionary conserved proteins, are
considered to be main elements of the cellular proteoprotection system. HSPs are encoded …

Abstract Heat shock protein 90 (Hsp90), a 90-kDa molecular chaperone, is responsible for
biological activities of key signaling molecules (clients) such as protein kinases, ubiquitin …

Background: Heat shock proteins (HSPs) are highly conserved proteins present in all
kingdoms of organisms. These are expressed under stress conditions in order to protect the …

The molecular chaperone Heat Shock Protein-90 (Hsp90) is known to interact with over 300
client proteins as well as regulatory factors (eg. nucleotide and proteins) that facilitate …

Rapid evaluation of therapies designed to preserve β cells in persons with type 1 diabetes
(T1D) is hampered by limited availability of sensitive β-cell health biomarkers. In particular …

Bullous pemphigoid is one of the most common autoimmune bullous diseases occurring
primarily in the elderly. Pathogenic autoantibodies against BP180 and BP230 at the dermal …

The aim of the treatment in autoimmune blistering diseases (AIBDs) is to induce and
maintain remission, which clinically corresponds to the cessation of new vesicle formation …