In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Peptides and proteins are preponderantly emerging in the drug market, as shown by the
increasing number of biopharmaceutics already approved or under development …

Microviridins and other ω-ester-linked peptides, collectively known as graspetides, are
characterized by side-chain–side-chain linkages installed by ATP-grasp enzymes. Here we …

Several classes of ribosomally synthesized and post-translationally modified peptides
(RiPPs) are composed of multiple macrocycles. The enzymes that assemble these …

Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for
infection, but how this binding event promotes the infection of host cells is unknown. Here …

The health of their populations and efficient health care systems are of critical importance to
the economic and social well-being of nations. Accurate and comparable peptide/protein …

Objective Glycation is a non-enzymatic and spontaneous post-translational modification
(PTM) generated by the reaction between reducing sugars and primary amine groups within …

Broadband microwave spectra of N-ethyl maleimide (NEM) and N-ethyl succinimide (NES)
have been recorded using chirped pulse Fourier transform microwave spectroscopy in the K …

The monitoring of non-enzymatic post-translational modifications (PTMs) in therapeutic
proteins is important to ensure drug safety and efficacy. Together with methionine and …

Detailed analysis of biopharmaceuticals is crucial for safety, efficacy and stability. Aptamers,
which are folded, single-stranded oligonucleotides, can be used as surrogate antibodies to …