8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

V Prachayasittikul, S Prachayasittikul… - Drug design …, 2013 - Taylor & Francis
Metal ions play an important role in biological processes and in metal homeostasis. Metal
imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's …

Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry

R Gupta, V Luxami, K Paul - Bioorganic chemistry, 2021 - Elsevier
Hydroxyquinoline (8-HQ) is a significant heterocyclic scaffold in organic and analytical
chemistry because of the properties of chromophore and is used to detect various metal ions …

Copper and antibiotics: discovery, modes of action, and opportunities for medicinal applications

AG Dalecki, CL Crawford, F Wolschendorf - Advances in microbial …, 2017 - Elsevier
Copper is a ubiquitous element in the environment as well as living organisms, with its redox
capabilities and complexation potential making it indispensable for many cellular functions …

Synthesis, dft calculations, antiproliferative, bactericidal activity and molecular docking of novel mixed-ligand salen/8-hydroxyquinoline metal complexes

BS Al-Farhan, MT Basha, LH Abdel Rahman… - Molecules, 2021 - mdpi.com
Despite the common use of salens and hydroxyquinolines as therapeutic and bioactive
agents, their metal complexes are still under development. Here, we report the synthesis of …

The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus

BW Obiang-Obounou, OH Kang, JG Choi… - The Journal of …, 2011 - jstage.jst.go.jp
Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria
canadensis. It is known to perform a wide spectrum of biological activities. The aim of this …

Supercharged precision killers: Genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni

X Wei, B Xue, S Ruan, J Guo, Y Huang, X Geng… - Science …, 2024 - science.org
To eliminate multidrug-resistant bacteria of Acinetobacter baumannii, we screened 1100
Food and Drug Administration–approved small molecule drugs and accessed the …

Types of microbicidal and microbistatic agents

I Al‐Adham, R Haddadin… - Russell, Hugo & Ayliffe's …, 2013 - Wiley Online Library
This chapter serves as a source of reference for those interested in developing an initial or
general understanding of the chemistry and mode of action of a particular group of …

The antibiotics resistance mechanism and pathogenicity of cold stressed Staphylococcus aureus

J Qiao, M Zhu, Z Lu, F Lv, H Zhao, X Bie - Lwt, 2020 - Elsevier
Staphylococcus aureus was one of the most common foodborne pathogens around the
world. S. aureus displayed strong tolerance to low temperature (4° C and− 20° C) at which …

[Au (pyb-H)(mnt)]: A novel gold (III) 1, 2-dithiolene cyclometalated complex with antimicrobial activity (pyb-H= C-deprotonated 2-benzylpyridine; mnt= 1, 2 …

A Pintus, MC Aragoni, MA Cinellu, L Maiore… - Journal of inorganic …, 2017 - Elsevier
The novel heteroleptic cyclometalated complex [Au III (py bH)(mnt)](1; py bH= C-
deprotonated 2-benzylpyridine; mnt= 1, 2-dicyanoethene-1, 2-dithiolate) was tested against …

Shigatoxin encoding Bacteriophage ϕ24B modulates bacterial metabolism to raise antimicrobial tolerance

GS Holt, JK Lodge, AJ McCarthy, AK Graham… - Scientific reports, 2017 - nature.com
How temperate bacteriophages play a role in microbial infection and disease progression is
not fully understood. They do this in part by carrying genes that promote positive …