PROTACs in gastrointestinal cancers
Y Chen, Q Yang, J Xu, L Tang, Y Zhang, F Du… - Molecular Therapy …, 2022 - cell.com
Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …
Molecular glue-mediated targeted protein degradation: A novel strategy in small-molecule drug development
X Tan, Z Huang, H Pei, Z Jia, J Zheng - Iscience, 2024 - cell.com
Small-molecule drugs are effective and thus most widely used. However, their applications
are limited by their reliance on active high-affinity binding sites, restricting their target …
are limited by their reliance on active high-affinity binding sites, restricting their target …
[HTML][HTML] Targeted protein degradation might present a novel therapeutic approach in the fight against African trypanosomiasis
AU Danazumi, IT Ishmam, S Idris, MA Izert… - European Journal of …, 2023 - Elsevier
African trypanosomiasis (AT) is a hemoparasitic disease caused by infection with African
trypanosomes and it is prevalent in many sub-Saharan African countries, affecting both …
trypanosomes and it is prevalent in many sub-Saharan African countries, affecting both …
PROTACs in Treatment of Glioma
S Kumar, V Maharshi - … -Mediated Protein Degradation: A Paradigm Shift in …, 2024 - Springer
Abstract Treatment for gliomas, especially glioblastoma (GBM), is extremely difficult because
of the disease's poor prognosis and low 5-year survival rate (less than 5%). There is an …
of the disease's poor prognosis and low 5-year survival rate (less than 5%). There is an …
[引用][C] PROTACs in gastrointestinal cancers
M Li, J Shen, R Ding, H Cao, W Li, X Li, M Chen… - Molecular …, 2022 - europepmc.org
Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …