Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of
patients respond to these immunotherapies. Here, we report that blocking the inhibitory …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …

Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a
complex senescence-associated secretory phenotype (SASP). The senescence arrest …

The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …

Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …