COVID-19: immunopathogenesis and Immunotherapeutics

L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected …

The land-scape of immune response to monkeypox virus

H Li, QZ Huang, H Zhang, ZX Liu, XH Chen, LL Ye… - …, 2023 - thelancet.com
Human monkeypox is a viral zoonotic smallpox-like disease caused by the monkeypox virus
(MPXV) and has become the greatest public health threat in the genus Orthopoxvirus after …

Antibody-mediated protection against Ebola virus

EO Saphire, SL Schendel, BM Gunn, JC Milligan… - Nature …, 2018 - nature.com
Recent Ebola virus disease epidemics have highlighted the need for effective vaccines and
therapeutics to prevent future outbreaks. Antibodies are clearly critical for control of this …

Molecular determinants of target cell recognition by human γδ T cells

AE Simões, B Di Lorenzo, B Silva-Santos - Frontiers in immunology, 2018 - frontiersin.org
The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed
conditions, particularly infected or transformed cells, and killing them or regulating the …

Long-lasting severe immune dysfunction in Ebola virus disease survivors

A Wiedemann, E Foucat, H Hocini, C Lefebvre… - Nature …, 2020 - nature.com
Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking.
Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the …

Immune characteristics of severe and critical COVID-19 patients

L Yang, J Gou, J Gao, L Huang, Z Zhu, S Ji… - Signal transduction and …, 2020 - nature.com
Recently, the novel coronavirus disease (COVID-19) has broken out worldwide, 1 with rapid
increase of infected patients. COVID-19 dominantly leads to pneumonia. 2 Among these …

Transcriptional correlates of tolerance and lethality in mice predict Ebola virus disease patient outcomes

A Price, A Okumura, E Haddock, F Feldmann… - Cell reports, 2020 - cell.com
Host response to infection is a major determinant of disease severity in Ebola virus disease
(EVD), but gene expression programs associated with outcome are poorly characterized …

The new kid on the block: HLA-C, a key regulator of natural killer cells in viral immunity

S Vollmers, A Lobermeyer, C Körner - Cells, 2021 - mdpi.com
The human leukocyte antigen system (HLA) is a cluster of highly polymorphic genes
essential for the proper function of the immune system, and it has been associated with a …

Inflammatory and humoral immune response during Ebola virus infection in survivor and fatal cases occurred in Sierra Leone during the 2014–2016 outbreak in West …

F Colavita, M Biava, C Castilletti, S Lanini, R Miccio… - Viruses, 2019 - mdpi.com
Ebola virus (EBOV) infection is characterized by an excessive inflammatory response, a loss
of lymphocytes and a general paralysis of the immune system, however pathophysiological …

Inhibiting the unconventionals: importance of immune checkpoint receptors in γδ T, MAIT, and NKT cells

E Catafal-Tardos, MV Baglioni, V Bekiaris - Cancers, 2021 - mdpi.com
Simple Summary All conventional major histocompatibility complex (MHC)-restricted T cells
transiently express immune checkpoint/inhibitory receptors (ICRs) following activation as a …