The glutamate receptor ion channels

R Dingledine, K Borges, D Bowie, SF Traynelis - Pharmacological reviews, 1999 - ASPET
The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

The induction of pain: an integrative review

MJ Millan - Progress in neurobiology, 1999 - Elsevier
The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Treatment of Alzheimer's disease; current status and new perspectives

P Schelterns, H Feldman - The Lancet Neurology, 2003 - thelancet.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the most
prevalent cause of dementia with ageing. Pharmacological treatment of AD is based on the …

Memantine for dementia

R McShane, AA Sastre… - Cochrane database of …, 2006 - cochranelibrary.com
Memantine for dementia - McShane, R - 2006 | Cochrane Library Skip to Content Cookies Our
site uses cookies to improve your experience. You can find out more about our use of cookies …

Neuropsychology and neuropharmacology of P3a and P3b

J Polich, JR Criado - International Journal of Psychophysiology, 2006 - Elsevier
Perspectives on the P300 event-related brain potential (ERP) are reviewed by outlining the
distinction between the P3a and P3b subcomponents. The critical factor for eliciting P3a is …

Glutamate receptors in the mammalian central nervous system

S Ozawa, H Kamiya, K Tsuzuki - Progress in neurobiology, 1998 - Elsevier
Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …

The role of excitotoxicity in neurodegenerative disease: implications for therapy

A Doble - Pharmacology & therapeutics, 1999 - Elsevier
Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …

Ca2+-Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

HG Wang, N Pathan, IM Ethell, S Krajewski… - Science, 1999 - science.org
The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism
is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the …

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

D Colquhoun - British journal of pharmacology, 1998 - ncbi.nlm.nih.gov
Binding, gating, a nity and e cacy Page 1 SEMINAR Binding, gating, a nity and e cacy The nature
of the problem Some history The classical era The interaction between binding and conformation …

[PDF][PDF] Memantine for dementia

R McShane, MJ Westby, E Roberts… - … Database Syst Rev, 2019 - cochranelibrary.com
Cochrane Page 1 Cochrane Library Cochrane Database of Systematic Reviews Memantine
for dementia (Review) McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L …