Covid-19 vaccines—immunity, variants, boosters

DH Barouch - New England Journal of Medicine, 2022 - Mass Medical Soc
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Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Correlates of protection against SARS-CoV-2 in rhesus macaques

K McMahan, J Yu, NB Mercado, C Loos, LH Tostanoski… - Nature, 2021 - nature.com
Recent studies have reported the protective efficacy of both natural and vaccine-induced,,,,–
immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS …

Immunogenicity of Ad26. COV2. S vaccine against SARS-CoV-2 variants in humans

G Alter, J Yu, J Liu, A Chandrashekar, EN Borducchi… - Nature, 2021 - nature.com
Abstract The Ad26. COV2. S vaccine,–has demonstrated clinical efficacy against
symptomatic COVID-19, including against the B. 1.351 variant that is partially resistant to …

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

NB Mercado, R Zahn, F Wegmann, C Loos… - Nature, 2020 - nature.com
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic …

Immunogenicity of the Ad26. COV2. S Vaccine for COVID-19

KE Stephenson, M Le Gars, J Sadoff, AM de Groot… - Jama, 2021 - jamanetwork.com
Importance Control of the global COVID-19 pandemic will require the development and
deployment of safe and effective vaccines. Objective To evaluate the immunogenicity of the …

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

J Yu, LH Tostanoski, L Peter, NB Mercado, K McMahan… - Science, 2020 - science.org
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine …

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

A Chandrashekar, J Liu, AJ Martinot, K McMahan… - Science, 2020 - science.org
An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global …

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

LH Tostanoski, F Wegmann, AJ Martinot, C Loos… - Nature medicine, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness,
but some individuals develop severe pneumonia, respiratory failure and death,,–. Studies of …

[HTML][HTML] Compromised humoral functional evolution tracks with SARS-CoV-2 mortality

T Zohar, C Loos, S Fischinger, C Atyeo, C Wang… - Cell, 2020 - cell.com
The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress
in the absence of well-defined correlates of immunity. While neutralization has been linked …