Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum
membrane and are responsible for the release of Ca2+ from intracellular stores during …

Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second
messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene …

The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the
coupling of excitation and contraction in cardiac muscle. Among various modulators …

Mice with a malignant hyperthermia mutation (Y522S) in the ryanodine receptor (RyR1)
display muscle contractures, rhabdomyolysis, and death in response to elevated …

▪ Abstract A surprising variety of ion channels found in a wide range of species from Homo to
Paramecium use calmodulin (CaM) as their constitutive or dissociable Ca2+-sensing …

LS Maier and DM Bers. Calcium, Calmodulin, and Calcium-Calmodulin Kinase II: Heartbeat
to Heartbeat and Beyond. Journal of Molecular and Cellular Cardiology (2002) 34, 919–939 …

The cardiac ryanodine receptor (RyR) is the sarcoplasmic reticulum (SR) Ca-release
channel which is centrally involved in the myocyte excitation–contraction (E–C) coupling …

Metabolically 35 S-labeled calmodulin (CaM) was used to determine the CaM binding
properties of the cardiac ryanodine receptor (RyR2) and to identify potential channel …

Excitation–contraction (EC) coupling comprises events in muscle that convert electrical
signals to Ca2+ transients, which then trigger contraction of the sarcomere. Defects in these …

Abstract Cav2. 1 channels, which mediate P/Q-type Ca2+ currents, undergo
Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter …