The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

The subcellular position of a protein is a key determinant of its function. Mounting evidence
indicates that RNA localization, where specific mRNAs are transported subcellularly and …

Growth faltering under 5 years of age is unacceptably high worldwide, and even more
children, while not stunted, fail to reach their growth potential. The time between conception …

Several preclinical and some clinical studies have revealed that the mammalian target of
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …

The translation of mRNA into polypeptides is a key step in eukaryotic gene expression.
Translation is mostly controlled at the level of initiation, which is partly regulated by the …

Elevated mammalian target of rapamycin (mTOR) signaling has been found in Alzheimer's
disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD …

Low doses of ketamine trigger rapid and lasting antidepressant effects after one injection in
treatment-resistant patients with major depressive disorder. Modulation of AMPA receptors …

Sleep deprivation is a public health epidemic that causes wide-ranging deleterious
consequences, including impaired memory and cognition. Protein synthesis in hippocampal …