Cardiovascular diseases are the leading cause of global deaths, and many risk factors
contribute to their pathogenesis. In this context, prostanoids, which derive from arachidonic …

A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …

Stroke is the second leading cause of global mortality and continued efforts aim to identify
predictive, diagnostic, or prognostic biomarkers to reduce the disease burden. Circulating …

Diabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives
maladaptive structural changes and functional damage to the vasculature. Attenuation of this …

Background Cardiac arrhythmia, a common cardiovascular disease, is closely related to
genetic polymorphisms. However, the associations between polymorphisms in KCNH2 and …

L1CAM-positive extracellular vesicles (L1EV) are an emerging biomarker that may better
reflect ongoing neuronal damage than other blood-based biomarkers. The physiological …

Novel genetic risk markers have helped us to advance the field of cardiovascular
epidemiology and refine our current understanding and risk stratification paradigms. The …

Background and Objectives Genome-wide association studies (GWASs) have only 2 loci
associated with spontaneous intracerebral hemorrhage (ICH): APOE for lobar and 1q22 for …

Background and Objectives Stroke genetic research has made substantial progress in the
past decade. Its recovery application, however, remains behind, in part due to its reliance on …

Atrial fibrillation (AF) is a common heart arrhythmia and a major cause of cardioembolic
stroke. Therefore, accurate prediction is desirable to allow high-risk individuals to be …