Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

[HTML][HTML] Decoding the neurocircuitry of gut feelings: Region-specific microbiome-mediated brain alterations

BL Sharvin, MR Aburto, JF Cryan - Neurobiology of Disease, 2023 - Elsevier
Research in the last decade has unveiled a crucial role for the trillions of microorganisms
that reside in the gut in influencing host neurodevelopment across the lifespan via the …

Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study

JE Hintikka, JP Ahtiainen, P Permi, S Jalkanen… - Scientific Reports, 2023 - nature.com
Physical activity is essential in weight management, improves overall health, and mitigates
obesity-related risk markers. Besides inducing changes in systemic metabolism, habitual …

Microbiota-gut-brain axis: Relationships among the vagus nerve, gut microbiota, obesity, and diabetes

S Longo, S Rizza, M Federici - Acta diabetologica, 2023 - Springer
Aims The purpose of this review is to explore the interconnected pathways of the microbiota-
gut-brain axis (MGBA), focusing on the roles of the vagus nerve and glucagon like peptide-1 …

Orexin neurons mediate temptation-resistant voluntary exercise

AL Tesmer, X Li, E Bracey, C Schmandt… - Nature …, 2024 - nature.com
Despite the well-known health benefits of physical activity, many people underexercise;
what drives the prioritization of exercise over alternative options is unclear. We developed a …

Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives

S Incontro, ML Musella, M Sammari… - Physiological …, 2025 - journals.physiology.org
Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Why do hosts malfunction without microbes? Missing benefits versus evolutionary addiction

TJ Hammer - Trends in Microbiology, 2024 - cell.com
Microbes are widely recognized to be vital to host health. This new consensus rests, in part,
on experiments showing how hosts malfunction when microbes are removed. More and …

Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases

JA Santiago, JA Potashkin - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases have reached alarming numbers in the past decade.
Unfortunately, clinical trials testing potential therapeutics have proven futile. In the absence …

Targeting the gut microbiota-related metabolites for osteoporosis: the inextricable connection of gut-bone axis

YW Zhang, Y Wu, XF Liu, X Chen, JC Su - Ageing research reviews, 2024 - Elsevier
Osteoporosis is a systemic skeletal disease characterized by decreased bone mass,
destruction of bone microstructure, raised bone fragility, and enhanced risk of fractures. The …

Contribution of the microbiome for better phenotyping of people living with obesity

A Di Ciaula, L Bonfrate, M Khalil, G Garruti… - Reviews in Endocrine …, 2023 - Springer
Obesity has reached epidemic proportion worldwide and in all ages. Available evidence
points to a multifactorial pathogenesis involving gene predisposition and environmental …