The mitochondria-mediated caspase activation pathway is a major apoptotic pathway
characterized by mitochondrial outer membrane permeabilization (MOMP) and subsequent …

Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a
suppressor of apoptosis and plays a central role in cell division. Survivin has been …

Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches
that contributes to cellular transformation and, ultimately, to invasive cancer. Much has been …

Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from
premature or inappropriate entry of cells into mitosis and can be caused by chemical or …

Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted
attention from several viewpoints of basic and translational research. Its cell cycle-regulated …

Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

Our somatic cells are born by mitosis and almost all will die by apoptosis, a physiological
process of cellular suicide. Cancers can occur when this balance is disturbed, either by an …

Midzone microtubules of mammalian cells play an essential role in the induction of cell
cleavage, serving as a platform for a number of proteins that play a part in cytokinesis. We …

Microtubules are dynamic polymers that play crucial roles in a large number of cellular
functions. Their pivotal role in mitosis makes them a target for the development of anticancer …

Survivin is a unique member of the inhibitor of apoptosis (IAP) protein family that interferes
with post-mitochondrial events including activation of caspases. Survivin regulates cell cycle …