Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

EA Donadi, EC Castelli, A Arnaiz-Villena… - Cellular and molecular …, 2011 - Springer
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …

HLA‐G: Function, polymorphisms and pathology

A Arnaiz‐Villena, I Juarez… - International Journal …, 2021 - Wiley Online Library
HLA‐G immune modulatory genes and molecules are presently being studied by a
widespread number of research groups. In the present study, we do not aim to be exhaustive …

The genetic structure of 3′ untranslated region of the HLA-G gene: polymorphisms and haplotypes

EC Castelli, CT Mendes-Junior, NHS Deghaide… - Genes & …, 2010 - nature.com
The HLA-G gene is predominantly expressed at the maternal–fetal interface. It has been
associated with maternal–fetal tolerance and in the inhibition of cytotoxic T lymphocyte and …

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

EC Castelli, J Ramalho, IOP Porto, THA Lima… - Frontiers in …, 2014 - frontiersin.org
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I
genes, located within the major histocompatibility complex (MHC). HLA-G has been the …

A Comprehensive Study of Polymorphic Sites along the HLA-G Gene: Implication for Gene Regulation and Evolution

EC Castelli, CT Mendes-Junior… - Molecular biology …, 2011 - academic.oup.com
HLA-G molecule plays an important role on immune response regulation and has been
implicated on the inhibition of T and natural killer cell cytolytic function and inhibition of …

In silico analysis of microRNAS targeting the HLA-G 3′ untranslated region alleles and haplotypes

EC Castelli, P Moreau, AO e Chiromatzo… - Human immunology, 2009 - Elsevier
It has been reported that microRNAs (miRNA) may have allele-specific targeting for the 3′
untranslated region (3′ UTR) of the HLA-G locus. In a previous study, we reported 11 3 …

HLA-G genotype/expression/disease association studies: success, hurdles, and perspectives

G Amodio, S Gregori - Frontiers in Immunology, 2020 - frontiersin.org
The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological
condition, HLA-G surface expression is restricted to the maternal–fetal interface and to …

HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage

P Moreau, L Contu, F Alba, S Lai, R Simoes… - Biology of …, 2008 - academic.oup.com
Definite causes for several pathologies of pregnancy remain unknown. In light of several
recent studies, however, diminished or aberrant HLA-G expression may be associated with …

Human leukocyte antigen-G (HLA-G) polymorphism and expression in breast cancer patients

S Jeong, S Park, BW Park, Y Park, OJ Kwon, HS Kim - PLoS One, 2014 - journals.plos.org
Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune
escape mechanism in malignancies. The purpose of this study was to investigate HLA-G …

Evolution and molecular interactions of major histocompatibility complex (MHC)-G,-E and-F genes

A Arnaiz-Villena, F Suarez-Trujillo, I Juarez… - Cellular and Molecular …, 2022 - Springer
Abstract Classical HLA (Human Leukocyte Antigen) is the Major Histocompatibility Complex
(MHC) in man. HLA genes and disease association has been studied at least since 1967 …