Excessive trabeculation, often referred to as “noncompacted” myocardium, has been
described at all ages, from the fetus to the adult. Current evidence for myocardial …

Spontaneous beat-to-beat variations of heart rate (HR) have intrigued scientists and casual
observers for centuries; however, it was not until the 1970s that investigators began to apply …

Complex genetic mechanisms are thought to underlie many human diseases, yet
experimental proof of this model has been elusive. Here, we show that a human cardiac …

Any reliable biomarker has to be specific, generalizable, and reproducible across
individuals and contexts. The exact values of such a biomarker must represent similar health …

Introduction: Fractality is omnipresent in medicine and life sciences. In particular, the fractal
principle is found simultaneously at different organization levels of the cell nucleus. The aim …

The remodeling of the compact wall by incorporation of trabecular myocardium, referred to
as compaction, receives much attention because it is thought that its failure causes left …

Abstract Background and Objective As a nonlinear framework in dynamical system analysis,
chaotic approaches are mainly applied to evolve the complexity of biological systems. Due …

If health can be defined as adaptability, then measures of adaptability are crucial.
Convergent findings across clinical areas established the notion that fractal properties in bio …

Fractional differential equations have become a fundamental modelling approach for
understanding and simulating the many aspects of non-locality and spatial heterogeneity of …

Background: Multifractal analysis of human heartbeat dynamics has been demonstrated to
provide promising markers of congestive heart failure (CHF). Yet, it crucially builds on the …