Biological roles of adenine methylation in RNA
K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI
C Liu, H Sun, Y Yi, W Shen, K Li, Y Xiao, F Li, Y Li… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …
Exon architecture controls mRNA m6A suppression and gene expression
N 6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
[HTML][HTML] Advances and trends in omics technology development
X Dai, L Shen - Frontiers in Medicine, 2022 - frontiersin.org
The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …
m6A RNA methylation: from mechanisms to therapeutic potential
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
Artificial intelligence-based multi-omics analysis fuels cancer precision medicine
With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …
emerging that have enabled researchers to access multi-layer information from the genome …
Reading, writing and erasing mRNA methylation
S Zaccara, RJ Ries, SR Jaffrey - Nature reviews Molecular cell biology, 2019 - nature.com
RNA methylation to form N 6-methyladenosine (m6A) in mRNA accounts for the most
abundant mRNA internal modification and has emerged as a widespread regulatory …
abundant mRNA internal modification and has emerged as a widespread regulatory …
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
B Yue, C Song, L Yang, R Cui, X Cheng, Z Zhang… - Molecular cancer, 2019 - Springer
Background As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …