Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches

AL Boxer, JT Yu, LI Golbe, I Litvan, AE Lang… - The Lancet …, 2017 - thelancet.com
Progressive supranuclear palsy (PSP), previously believed to be a common cause of
atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes …

Magnetic resonance imaging for the diagnosis of Parkinson's disease

B Heim, F Krismer, R De Marzi, K Seppi - Journal of neural transmission, 2017 - Springer
The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

Radiological biomarkers for diagnosis in PSP: where are we and where do we need to be?

JL Whitwell, GU Höglinger, A Antonini… - Movement …, 2017 - Wiley Online Library
ABSTRACT PSP is a pathologically defined neurodegenerative tauopathy with a variety of
clinical presentations including typical Richardson's syndrome and other variant PSP …

Progressive supranuclear palsy: Advances in diagnosis and management

DG Coughlin, I Litvan - Parkinsonism & related disorders, 2020 - Elsevier
Progressive supranuclear palsy (PSP) is a complex clinicopathologic disease with no
current cure or disease modulating therapies that can only be definitively confirmed at …

Differentiation of neurodegenerative parkinsonian syndromes by volumetric magnetic resonance imaging analysis and support vector machine classification

HJ Huppertz, L Möller, M Südmeyer… - Movement …, 2016 - Wiley Online Library
Background Clinical differentiation of parkinsonian syndromes is still challenging. Objectives
A fully automated method for quantitative MRI analysis using atlas‐based volumetry …

A new MR imaging index for differentiation of progressive supranuclear palsy-parkinsonism from Parkinson's disease

A Quattrone, M Morelli, S Nigro, A Quattrone… - Parkinsonism & related …, 2018 - Elsevier
Introduction Differentiating clinically progressive supranuclear palsy-parkinsonism (PSP-P)
from Parkinson's disease (PD) may be challenging, especially in the absence of vertical …

Clinical spectrum of tauopathies

N Olfati, A Shoeibi, I Litvan - Frontiers in Neurology, 2022 - frontiersin.org
Tauopathies are both clinical and pathological heterogeneous disorders characterized by
neuronal and/or glial accumulation of misfolded tau protein. It is now well understood that …

Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial

GU Höglinger, HJ Huppertz, S Wagenpfeil… - Movement …, 2014 - Wiley Online Library
It is believed that glycogen synthase kinase‐3 hyperphosphorylates tau protein in
progressive supranuclear palsy (PSP). The Tau Restoration on PSP (TAUROS) trial …

Automated MRI classification in progressive supranuclear palsy: a large international cohort study

S Nigro, A Antonini, DE Vaillancourt… - Movement …, 2020 - Wiley Online Library
Abstract Background The Magnetic Resonance Parkinsonism Index is listed as one of the
most reliable imaging morphometric markers for diagnosis of progressive supranuclear …

Accurate measurement of magnetic resonance parkinsonism index by a fully automatic and deep learning quantification pipeline

F Sun, J Lyu, S Jian, Y Qin, X Tang - European radiology, 2023 - Springer
Objectives This study aims at a fully automatic pipeline for measuring the magnetic
resonance parkinsonism index (MRPI) using deep learning methods. Methods MRPI is …