Mechanisms and roles of podosomes and invadopodia

S Linder, P Cervero, R Eddy, J Condeelis - Nature Reviews Molecular …, 2023 - nature.com
Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Macrophages, foreign body giant cells and their response to implantable biomaterials

Z Sheikh, PJ Brooks, O Barzilay, N Fine, M Glogauer - Materials, 2015 - mdpi.com
All biomaterials, when implanted in vivo, elicit cellular and tissue responses. These
responses include the inflammatory and wound healing responses, foreign body reactions …

[HTML][HTML] An overview of the derivation and function of multinucleated giant cells and their role in pathologic processes

PJ Brooks, M Glogauer, CA McCulloch - The American journal of pathology, 2019 - Elsevier
Monocyte lineage cells play important roles in health and disease. Their differentiation into
macrophages is crucial for a broad array of immunologic processes that regulate …

Divergent regulation of basement membrane trafficking by human macrophages and cancer cells

JC Bahr, XY Li, TY Feinberg, L Jiang… - Nature …, 2022 - nature.com
Macrophages and cancer cells populations are posited to navigate basement membrane
barriers by either mobilizing proteolytic enzymes or deploying mechanical forces …

Probing the mechanical landscape–new insights into podosome architecture and mechanics

K van den Dries, S Linder… - Journal of cell …, 2019 - journals.biologists.com
Podosomes are dynamic adhesion structures formed constitutively by macrophages,
dendritic cells and osteoclasts and transiently in a wide variety of cells, such as endothelial …

Blood leukocytes and macrophages of various phenotypes have distinct abilities to form podosomes and to migrate in 3D environments

C Cougoule, E Van Goethem, V Le Cabec… - European journal of cell …, 2012 - Elsevier
Leukocytes migrate through most tissues in the body, a process which takes place in 3D
environments. We have previously shown that macrophages use the amoeboid migration …

Tools of the trade: podosomes as multipurpose organelles of monocytic cells

S Linder, C Wiesner - Cellular and molecular life sciences, 2015 - Springer
Podosomes are adhesion and invasion structures that are particularly prominent in cells of
the monocytic lineage such as macrophages, dendritic cells, and osteoclasts. They are …

Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine

WJ Gao, JX Liu, Y Xie, P Luo, ZQ Liu, L Liu… - Pharmacological …, 2021 - Elsevier
A large number of macrophages in inflamed sites not only amplify the severity of
inflammatory responses but also contribute to the deleterious progression of many chronic …

An efficient siRNA‐mediated gene silencing in primary human monocytes, dendritic cells and macrophages

A Troegeler, C Lastrucci, C Duval… - Immunology and cell …, 2014 - Wiley Online Library
Mononuclear phagocytes (MP) comprise monocytes, macrophages (MΦ) and dendritic cells
(DC), including their lineage‐committed progenitors, which together have an eminent role in …

Podosomes in space: macrophage migration and matrix degradation in 2D and 3D settings

C Wiesner, V Le-Cabec, K El Azzouzi… - Cell adhesion & …, 2014 - Taylor & Francis
Migration of macrophages is a key process for a variety of physiological functions, such as
pathogen clearance or tissue homeostasis. However, it can also be part of pathological …