Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …

Apoptosis, necrosis, or autophagy are diverse types of regulated cell death (RCD),
recognized as the strategies that host cells use to defend against pathogens such as …

Background Acute liver failure (ALF) is a syndrome of severe hepatocyte injury with high rate
of mortality. Hepatitis B virus (HBV) infection is the major cause of ALF worldwide, however …

Hepatitis B virus X protein (HBx) and hepatic stellate cells (HSCs) are critical for liver fibrosis
development. Anti-fibrosis occurs via reversion to quiescent-type HSCs or clearance of …

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in
epithelial tissues. EpCAM forms intercellular, homophilic adhesions, modulates epithelial …

Tumors are renowned as intricate systems that harbor heterogeneous cancer cells with
distinctly diverse molecular signatures, sizes and genomic contents. Among those various …

Hepatic fibrosis is a complex mechanism defined by the net deposition of the extracellular
matrix (ECM) owing to liver injury caused by multiple etiologies such as viral hepatitis and …

Abstract Polo-like kinase 1 (PLK1) is a conserved mitotic serine-threonine protein kinase,
functions as a regulatory protein, and is involved in the progression of the mitotic cycle. It …

During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological
condition caused by virus-induced liver damage. The activation of hepatic stellate cells …

Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and
poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including …