Freezing of gait: promising avenues for future treatment

M Gilat, ALS de Lima, BR Bloem, JM Shine… - Parkinsonism & related …, 2018 - Elsevier
Freezing of gait is a devastating symptom of Parkinson's disease and other forms of
parkinsonism. It poses a major burden on both patients and their families, as freezing often …

Recent advances in silicon-based neural microelectrodes and microsystems: a review

Z Fekete - Sensors and Actuators B: Chemical, 2015 - Elsevier
Developments in neurotechnology are recently driven by newly national and international
brain research initiatives worldwide. The challenging goal of understanding how the human …

Human gene therapy approaches for the treatment of Parkinson's disease: An overview of current and completed clinical trials

FL Hitti, AI Yang, P Gonzalez-Alegre… - Parkinsonism & related …, 2019 - Elsevier
Gene therapy has been employed in the human brain for a number of disorders in clinical
trials and may serve as an avenue for the treatment of Parkinson's disease (PD). Several …

Spatiotemporal expression of RNA-Seq identified proteins at the electrode interface

CH Thompson, BM Evans, DX Zhao, EK Purcell - Acta Biomaterialia, 2023 - Elsevier
Implantation of electrodes in the brain can be used to record from or stimulate neural tissues
to treat neurological disease and injury. However, the tissue response to implanted devices …

Mechanisms and Targeting of Deep-Brain Stimulation Therapies

AMK Brinda, MD Johnson - Handbook of Neuroengineering, 2022 - Springer
Deep-brain stimulation (DBS) is an effective neurosurgical treatment option for individuals
with medication-refractory brain disorders. DBS therapy involves sending high-frequency …