Introduction 3. Rho GTPase effectors 3.1. Rac/Cdc42/PAK 3.2. Rho/ROCK 3.3. Cdc42/ACK
4. Rho GTPases, neuronal growth cone dynamics, and dendritic spine morphogenesis 5 …

The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …

Background Parkinson's disease (PD) is a neurodegenerative disease with an often
complex component identifiable by genome‐wide association studies. The most recent large …

Objectives: This study aimed to identify the genetic defect in a family with idiopathic
ventricular fibrillation (IVF) manifesting in childhood and adolescence. Background …

Ribosome-associated quality control (RQC) pathway is responsible for degradation of
nascent polypeptides in aberrantly stalled ribosomes, and its defects may lead to …

The serine threonine kinase Akt is a core survival factor that underlies a variety of human
diseases. Although regulatory phosphorylation and dephosphorylation have been well …

A comprehensive representation of the gene content of the long arm of human chromosome
21 (Hsa21q) remains of interest for the study of Down syndrome, its associated phenotypic …

Although Alzheimer's disease (AD) is a central nervous system disease and type 2 diabetes
MELLITUS (T2DM) is a metabolic disorder, an increasing number of genetic epidemiological …

Down syndrome (DS), the most frequent genetic disorder leading to mental retardation (MR),
is caused by three copies of human chromosome 21 (HC21). Trisomic and transgenic …

Atrazine is one of the common herbicides with an annual usage of 70,000–90,000 tons
worldwide. Due to its long half-life (> 60 days), atrazine persists in water and soil for long …