An increase in centrosome number is commonly observed in cancer cells, but the role
centrosome amplification plays along with how and when it occurs during cancer …

Centrosomes are major organizing components of the tubulin-based cytoskeleton. In recent
years, we have gained extensive knowledge about their structure, biogenesis, and function …

Centrosome abnormalities are hallmarks of human cancers. Structural and numerical
centrosome abnormalities correlate with tumor aggressiveness and poor prognosis …

Centrosome amplification is a feature of cancer cells associated with chromosome instability
and invasiveness. Enhancing chromosome instability and subsequent cancer cell death via …

The spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing
progression from metaphase to anaphase until all chromosomes are correctly attached to …

High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and
extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a …

The presence of supernumerary centrosomes is a hallmark of cancer and is frequently
observed in aggressive tumors. Cancer cells with centrosome amplification achieve pseudo …

Background Abnormalities in centrosome regulatory genes can induce chromosome
instability, cell differentiation errors, and tumorigenesis. However, a limited number of …

Aging exhibits several hallmarks in common with cancer, such as cellular senescence,
dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades …

Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with
colon cancer - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …