Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …

Individuals can be deemed to have radiologically isolated syndrome (RIS) if they have
incidental demyelinating-appearing lesions in their brain or spinal cord that are highly …

Metabolomics-based technologies map in vivo biochemical changes that may be used as
early indicators of pathological abnormalities prior to the development of clinical symptoms …

Hepatocyte nuclear factor 4 α (HNF4α), a transcription factor (TF) essential for embryonic
development, has been recently shown to regulate the expression of inflammatory genes. To …

Peripheral blood mononuclear cells (PBMCs) bear specific dysregulations in genes and
pathways at distinct stages of multiple sclerosis (MS) that may help with classifying MS and …

While waiting for a vaccine, therapeutic alternatives to slow or stop the ongoing COVID-19
pandemic caused by the newly emerged severe acute respiratory syndrome coronavirus 2 …

Orofacial pain and headache disorders are among the most debilitating pain conditions.
While the pathophysiological basis of these disorders may be diverse, it is generally …

Multiple sclerosis (MS) is a neurological disorder characterized by immune dysregulation. It
begins with a first clinical manifestation, a clinically isolated syndrome (CIS), which evolves …

Recent evidence indicates that single multiple sclerosis (MS) susceptibility genes involved
in interferon (IFN) signaling display altered transcript levels in peripheral blood of untreated …

Multiple sclerosis (MS) is a complex inflammatory disease affecting the central nervous
system. Most commonly, it begins with recurrent symptoms followed by partial or complete …